Fertility answers for couples, beyond guidelines. by Locus Medicus
A holistic investigation of both partners, cause-oriented treatment and patented diagnostics, built on 28 years of subfertility research in Athens.
Couple subfertility
Subfertility is rarely one partner’s problem. We investigate the couple as one biological unit.
It is often the result of how two reproductive systems work together: small variations that are harmless on their own can add up. That is why we assess both partners together, identify every underlying cause and correct it before the next attempt to conceive, naturally or through IVF.
Our approach31
years of clinical & research excellence
28
years specialising in couple subfertility
17,000+
couples from Greece and abroad
15
scientists reviewing every case
Subfertility at Locus Medicus
Everything a couple needs, under one roof.
Diagnostic laboratories in cytogenetics, molecular pathology, cell biology and immunology work side by side with specialised clinics, so every finding turns into a decision quickly.
Infertility & Miscarriage Clinic
Counselling, investigation and treatment of subfertility and recurrent miscarriage, led by Dr Vassilis Tsilivakos.
Diagnostic Testing (HCSI™)
The Holistic Couple Subfertility Investigation: egg and sperm quality, endometrial receptivity and an office hysteroscopy.
Cause-Oriented Treatment
No treatment without a clear finding. We treat what the investigation reveals and avoid what it doesn’t.
Network of Specialists
Gynaecologists, an andrologist, immunologists, geneticists and an infection specialist working on one plan.
Scientific Research
Original research and three patented methods for the most complex cases.
4-Day Fertility Travel in Athens
For couples who live far away: diagnosis and the first crucial phase of treatment in one visit.
Our signature service
The 4-Day Fertility Travel in Athens
Because subfertility is often multifaceted and treatment takes time, our scientists designed a four-working-day visit for couples who live far away.
To complete the diagnostic assessment and the first, crucial phase of treatment.
Fresh biological specimens
Semen and endometrial samples cannot be transported or assessed remotely with the same reliability.
Immediate treatment
No time is wasted: first treatments begin as soon as results are available, scheduling permitting.
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Day 1
Medical history & sample collection
- 1st consultation (90 min) with Dr Vassilis Tsilivakos; it can also take place remotely via Teams.
- Collection of biological samples for every essential investigation of the Holistic Subfertility Assessment (HCSI™).
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Day 2
Laboratory investigations
- Analysis of the samples in the Locus Medicus research laboratories.
- Office hysteroscopy, if clinically necessary.
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Day 3
Preliminary results & first treatment
- A brief consultation to review the initial laboratory findings.
- Start of the first clinical treatments (LIT, intrauterine washes etc.) where indicated, under gynaecological supervision.
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Day 4
Final diagnosis & personalised guidance
- 2nd consultation (60 min): the diagnosis, with personalised medical guidance.
- Individualised treatments in a clearly defined sequence, plus further investigations if required.
Fertility Journey by Locus Medicus
Six steps, one couple, one plan.
A structured path that joins specialised diagnosis with targeted treatment, so every attempt starts with the best possible chances.
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01
1st consultation
Medical history assessment
The fertility specialist assesses both partners’ histories together and selects targeted tests and methods.
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02
Comprehensive testing
HCSI™
Egg and sperm quality and endometrial receptivity, including an office hysteroscopy.
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03
2nd consultation
Results & diagnosis
Results are reviewed, extra tests added only if needed, and a treatment plan is set.
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04
Targeted treatment
Precisely timed
Treatments follow a coordinated timeline agreed by the specialist and the scientific team.
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05
3rd consultation
Outcome assessment
We assess the outcome and set clear recommendations for the attempt to conceive.
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06
Conception attempt
Natural or IVF
Once fertility is at its best, with our support through the first trimester.
25years
of pioneering subfertility research in Athens
Why in Greece?
A national challenge that made us research earlier.
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The social context
Over recent decades, Greek couples have started families later than the global average.
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The demographic reality
As a result, the infertility rate in Greece has risen well above the global average of 15%.
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The scientific response
Our clinical scientists began in-depth research earlier than their peers abroad, first on immunology and thrombophilia and, since 2010–2012, with a holistic approach that investigates both partners together.
Beyond guidelines
We look at every factor before the next attempt.
Every related parameter is investigated and corrected as far as possible, so the couple comes to the next attempt with the maximum chance of success. That can mean success with the first IVF cycle, or a natural conception, with less time, medication, cost and emotional strain.
Endometrium
Immunological factors, thrombophilic predisposition, genital tract infections.
Eggs
Sufficiency, correct ovulation, correct chromosomal composition.
Sperm
Sufficiency, quality, DNA integrity, viral involvement, chromosomes.
Scientific research
Patented methods for the most complex cases.
We don’t just run tests: we produce original research and protected know-how, published in international journals and recognised with congress awards and innovation prizes.
Sperm Quality Enhancement
Treatment of high-viscosity semen with DNase, improving its suitability for assisted reproduction.
O.B.I. Patent No. 1008650
SPI TEST™
Detection of intracellular infectious agents inside sperm cells.
O.B.I. Patent No. 1008033
Hidden-C® Test
A painless test for chronic endometritis using menstrual tissue, with no endometrial biopsy, to reduce the risk of implantation failure and miscarriage.
O.B.I. Patent No. 1004154
20+
international publications
80+
congress participations
9
PhD theses with our labs
4
international scientific awards
Network of specialised scientists
The specialists behind every answer.
A network of specialised clinics covering every diagnostic and therapeutic need of the couple, throughout their fertility journey.
Vassilis X. Tsilivakos MD, PhD
Infertility Specialist · Perinatal Immunologist · Histopathologist
Founder of the Locus Medicus subfertility & miscarriage laboratory; 29+ years, 17,000+ couples.
Vassilis K. Kapetanios MD, PhD
Obstetrician – Gynaecologist · IVF Specialist
Trained in London; office hysteroscopy, endometritis and recurrent miscarriage.
Konstantinos Makarounis MD, PhD, FEBU, FECSM
Urologist – Andrologist
Male infertility, microsurgery (Micro-TESE), sperm infections and DNA fragmentation.
Christodoulos Papanikopoulos MD
Obstetrician – Gynaecologist · IVF Specialist
25+ years in assisted reproduction; 5,000+ successful IVF cycles.
Also in the network
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Georgios Georgoulias MD
Medical Biopathologist · Genital Tract Infection Specialist
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Nikolaos Georgakopoulos MSc
Molecular Biologist – Geneticist
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Michail Leventopoulos MSc, PhD
Neuroscientist – Immunologist · R&D
About us
31 years of clinical & research excellence.
Locus Medicus is a diagnostic centre and multispecialty clinic in Athens with a strong focus on research. Since 1998, couple subfertility has been our main specialisation, continually enriched with new methods after daily review by our 15 scientists.
Every couple deserves a unique approach.
Our vision: a comprehensive, personalised, holistic investigation that improves the chances of success while reducing the physical, emotional and financial burden.
Watch
Fertility Journey by Locus Medicus
A short presentation of how we investigate and treat couple subfertility, from the first consultation to conception.
Contact
Start your journey with an answer.
Tell us a little about yourselves and our team will contact you to arrange a first consultation in Athens or online, or to plan your 4-Day Fertility Travel.
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Next to Cholargos metro station · free parking for patients